Preparation of injectable 3D-formed .BETA.-tricalcium phosphate bead/alginate composite for bone tissue engineering

Preparation of injectable 3D-formed beta-tricalcium phosphate bead/alginate composite for bone tissue engineering.

A novel, injectable bone tissue engineering material was developed that consisted of beta-tricalcium phosphate (beta-TCP) beads as the solid phase and alginate as the gel phase. To prepare the instantaneously formed composite scaffold, an aqueous calcium chloride solution was dried on the surface of beta-TCP beads and crosslinked with an alginic acid sodium solution, thereby forming stable beta...

Design of injectable bone tissue engineering scaffold consists of ß-tricalcium phosphate beads and alginate

Microstereolithography-Based Fabrication of Anatomically Shaped Beta-Tricalcium Phosphate Scaffolds for Bone Tissue Engineering

Porous ceramic scaffolds with shapes matching the bone defects may result in more efficient grafting and healing than the ones with simple geometries. Using computer-assisted microstereolithography (MSTL), we have developed a novel gelcasting indirect MSTL technology and successfully fabricated two scaffolds according to CT images of rabbit femur. Negative resin molds with outer 3D dimensions c...

Biomimetic Calcium Phosphate-Polycarbonate Composite Scaffolds for Bone Tissue Engineering

Shuang S Chen and Joachim Kohn New Jersey Center for Biomaterials, Rutgers The State University of New Jersey, Piscataway, New Jersey 08854, United States. Statement of Purpose: Large bone defects resulting from trauma, tumor resection, congenital abnormalities or reconstructive surgery are challenging clinical problems that are usually treated with autografts and allografts. However, donor sit...

Vascularization of repaired limb bone defects using chitosan-β-tricalcium phosphate composite as a tissue engineering bone scaffold.

Ensuring histocompatibility in the tissue engineering of bones is a complex issue. The aim of this study was to observe the feasibility of chitosan-β-tricalcium phosphate composite in repairing limb bone defects, and to evaluate the therapeutic effects on osteogenesis. Beagle mesenchymal stem cells (MSCs) were divided into an experimental group that was cultured with an injectable form of chito...